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Nikolsky's sign is a clinical dermatological sign, named after Pyotr Nikolsky (1858–1940), a Russian physician who trained and worked in Ukraine, which was part of the Russian Empire at that time. The sign is present when slight rubbing of the skin results in exfoliation of the outermost layer.〔(【引用サイトリンク】title=eMedicine - Pemphigus Foliaceus : Article by Robert A Schwartz )〕〔Nikolski PV. Materiali K.uchenigu o pemphigus foliaceus (thesis ). Kiev. 1896.〕〔(【引用サイトリンク】title=MedilinePlus: Nikolsky’s sign )〕 Nikolsky's sign is almost always present in toxic epidermal necrolysis and is associated with pemphigus vulgaris.〔Ma, O. Emergency Medicine Manual. McGraw Hill. 2004.〕 It is useful in differentiating between pemphigus vulgaris or mucous membrane pemphigoid (where it is present) and bullous pemphigoid (where it is absent). The Nikolsky sign is dislodgement of intact superficial epidermis by a shearing force, indicating a plane of cleavage in the skin. Also present in Scalded Skin Syndrome caused by the exfoliative toxin of S. aureus. ==See also== *Chronic blistering skin diseases *Asboe-Hansen sign *List of cutaneous conditions 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Nikolsky's sign」の詳細全文を読む スポンサード リンク
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